Effect of intravenous ondansetron on arterial blood pressure

Evaluation of intravenous ondansetron on hypotension during cesarean section

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017033025600N3

Enrollment

Registered

2017-04-15

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anesthesia induced hypotension during cesarean section. Other complications of spinal and epidural anaesthesia during labour and delivery

Interventions

Intervention 1: Intravenous administration of 6 milligram ondansetron 5 minutes before spinal anesthesia. Intervention 2: Intravenous administration of 5 milliliters of normal saline solution 5 minute

Treatment - Drugs

Placebo

Intravenous administration of 6 milligram ondansetron 5 minutes before spinal anesthesia

Intravenous administration of 5 milliliters of normal saline solution 5 minutes before spinal anesthesia

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Parturients aged at 20-40 years old with American Society of Anesthesiologists (ASA) class I-II scheduled for the elective cesarean section with spinal anesthesia Exclusion criteria: History of hypertension; antihypertension drugs consumption; gastrointestinal diseases; motion sickness; allergy to ondansetron; glaucoma; preeclampsia; eclampsia; psychotic disorders and antiemetic drugs use during last 24 hours

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hypotension during cesarean section. Timepoint: at minutes 0,3,6,10,15,20,25,30. Method of measurement: None invasive blood pressure measuring.	—

Secondary

Measure	Time frame
Nausea during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.;Vomiting during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.;Shivering during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.	—

Measure

Time frame

Nausea during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.;Vomiting during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.;Shivering during surgery and stay in recovery unit. Timepoint: At any time during surgery and stay in recovery unit. Method of measurement: By asking the patient.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shahram Shokohi

Urmia University Of Medical Sciences

shokohi.sh@umsu.ac.ir, shokohi725@yahoo.com, dr.s.shokohi@gmail.com+98 44 3346 8967

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026