Comparing the relaxation effect of diazepam of oral administration of single and divided dose in Patients with limited mouth opening origin of masticatory muscles

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017032933167N1

Enrollment

Registered

2017-05-15

Start date

2017-04-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

limitation of mouth opening due to masticatory muscles. Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention 1: oral diazepam 10 mg/ 1 tab daily maximum for 1 week. Intervention 2: oral diazepam 5 mg/ 2 tab daily maximum for 1 week. Intervention 3: oral diazepam 2.5 mg/ 4 tab daily maximu

Treatment - Drugs

oral diazepam 10 mg/ 1 tab daily maximum for 1 week

oral diazepam 5 mg/ 2 tab daily maximum for 1 week

oral diazepam 2.5 mg/ 4 tab daily maximum for 1 week

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria:Pregnancy:Breastfeeding;using Drugs have interactions with diazepam (such as cimetidine, Amvprazvl, phenytoin, erythromycin and fungicides);Liver and kidney disfunctions (with tests SGOT, SGPT, ALP, Bun-Creatinine); alcoholism; glaucoma; severe difficulty breathing; Sleep Apnea; Epilepsy;Consumers of other benzodiazepines; other muscle relaxants and anti-inflammatory drugs; close lock; the joint disorders; chronic slow mandible; patients with submucosal fibrosis; patients radiotherapy; Sensitivity to diazepam Inclusion criteria:;Patients with limitation in mouth opening by the source of masticatory muscle

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Range of mouth opening. Timepoint: before Intervention and in 3,5 and 7 days after Intervention. Method of measurement: the distance between inscisal edge of two right centrals in milimeter.	—

Secondary

Measure	Time frame
Pain through opening. Timepoint: before Intervention and in 3,5 and 7 days after Intervention. Method of measurement: VAS(visual analog scale).;Drug complications. Timepoint: before Intervention and in 3,5 and 7 days after Intervention. Method of measurement: patient's discription.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeda Jarahi

Dental Faculty of Mashhad University

jarrahin921@mums.ac.ir+98 38067117

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026