Calculus of gallbladder without cholecystitis. Cholecystolithiasis Cholelithiasis Colic (recurrent) of gallbladder Gallstone (impacted) of: cystic duct gallbladder unspecified or without cholecystitis
Conditions
Interventions
Intervention 1: intraperitoneal and local bupivacaine 0.5%. The maximum dose was 2 mg per kilogram.
At the end of surgery and just one time. Intervention 2: 0.5 mg per kg intravenous acetazola
Prevention
intraperitoneal and local bupivacaine 0.5%. The maximum dose was 2 mg per kilogram.
At the end of surgery and just one time
0.5 mg per kg intravenous acetazolamide
Once at the end of the surgery
2 cc intravenous saline as placebo
Once at the end of the surgery
Sponsors
Vice Chancellor for research of Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: having physical status I or II of the ASA system (American Society of Anesthesiologists); aged 20 to 60 years; who were candidate for laparoscopic cholecystectomy surgery due to gallstone. Exclusion criteria: Patients who do not consent to be included in the study; bile duct problems; acute cholecystitis; lack of ability to understand and use visual analogue scale (VAS); experience of sensitivity to NSAIDs and local anesthetics; class III and IV of ASA system; patients with choledocolitiasis; and drain in situ.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: visual analog scale.;Paracetamol usage. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: according to patient documents. | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: documentd by doctor.;Systolic blood pressure. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: documentd by doctor.;Diastolic blood pressure. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: documentd by doctor.;Respiratory rate. Timepoint: just after surgery then 1, 4, 8, 12, and 24 hour after that. Method of measurement: documentd by doctor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Alireza Negahi
Surgery ward, Rasool Akram hospital
Outcome results
None listed