Effects of antibiotics on infection reduction

Comparing the effects of post-operative prescription or non-prescription of ceftriaxone and metronidazole on infection reduction of patients operated with simple appendicitis: A clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017031617756N12

Enrollment

150

Registered

2017-03-29

Start date

2017-05-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection complications. Infection following a procedure, not elsewhere classified

Interventions

Intervention 1: Control Group: They will receive antibiotics preoperatively, including ceftriaxone and metronidazole. Ceftriaxone will be prescribed as 1 gram for adults and 50 mg/kg/day for children.

Treatment - Drugs

Control Group: They will receive antibiotics preoperatively, including ceftriaxone and metronidazole. Ceftriaxone will be prescribed as 1 gram for adults and 50 mg/kg/day for children. Metronidazole w

Intervention group: They will receive antibiotics preoperatively, including ceftriaxone and metronidazole. Ceftriaxone will be prescribed as 1 gram for adults and 50 mg/kg/day for children. Metronidaz

Eligibility

Sex/Gender

All

Age

15 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between 15 and 75 years; patients who have undergone surgery for acute appendicitis; patients with a and body mass index lower than 25; absence of advanced appendicitis (i.e., gangrene, perforation, peritonitis, or phlegmon) or normal appendicitis; lack of severe underlying or chronic diseases such as diabetes. Exclusion criteria: Unwillingness to continue participation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Wound infection. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination.;Abdominal abscess. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination and, if needed, by ultrasonography.;Pelvic abscess. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination and, if needed, by ultrasonography.	—

Measure

Time frame

Wound infection. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination.;Abdominal abscess. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination and, if needed, by ultrasonography.;Pelvic abscess. Timepoint: During hospitalization, first and second weeks after operation. Method of measurement: Physical examination and, if needed, by ultrasonography.

—

Secondary

Measure	Time frame
Fever. Timepoint: During hospitalization. Method of measurement: Thermometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Samimi

Birjand University of Medical Sciences

Saharsamimi65@yahoo.com+98 56 3239 5680

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026