The effect of herbal toothpaste containing berberine and saponin on oral and dental health

Clinical trial comparing the effect of standard toothpaste and herbal toothpaste containing berberine and saponin on dental plaque, gingival inflammation, and salivary bacterial count

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170316033099N13

Enrollment

Registered

2021-05-02

Start date

2021-05-22

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral and dental health. Gingivitis and periodontal diseases

Interventions

Intervention 1: Intervention group 1 (standard toothpaste): After the correct manner of brushing is trained to them, participants will brush their teeth twice daily for 3-5 minutes for a period of sev

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having a minimum of 24 teeth Signing informed consent form for participation in the study Non-consumption of antibiotics from 2 weeks before saliva sampling

Exclusion criteria

Exclusion criteria: Presence of systemic problems such as diabetes Presence of cavities

Design outcomes

Primary

Measure	Time frame
Dental plaque. Timepoint: baseline, months 3, 5, and 7 after baseline. Method of measurement: Plaque Index.;Gingival inflammation. Timepoint: baseline, months 3, 5, and 7 after baseline. Method of measurement: Gingival Index.;Lactobacillus and Streptococcus mutans bacteria. Timepoint: baseline, months 3, 5, and 7 after baseline. Method of measurement: saliva swab.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hamid Ahmadi

Birjand University of Medical Sciences

hamid.ahmd.97@gmail.com+98 56 3238 1708

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026