migraine. Migraine
Conditions
Interventions
Intervention 1: Intervention group 1 (propranolol): propranolol, 20 mg oral tablets, once daily for three months. Intervention 2: Intervention group 2 (propranolol plus melatonin): 20 mg propranolol t
Sponsors
Birjand University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Confirmed migraine as per the indices of the International Headache Society Age between 18 and 65 years Residence in South Khorasan Province An average of two migraine attacks per month A minimum of one-year history of migraine The first migraine attack occurring before age 50 Informed consent for participation
Exclusion criteria
Exclusion criteria: History of headaches lasting longer than 15 days a month History of any neurological disorder other than migraine Allergy to the study medications Presence of debilitating diseases such as cancer and autoimmune diseases, advanced diabetes, etc. Pregnancy and lactation Persistent headache History of seizures and epilepsy History of neurological and mental illnesses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain severity. Timepoint: study onset, fourth week, eighth week, and twelfth week. Method of measurement: visual analog scale.;Pain duration. Timepoint: fourth week, eighth week, and twelfth week. Method of measurement: patient's report.;Number of migraine attacks. Timepoint: fourth week, eighth week, and twelfth week. Method of measurement: patient's report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSajjad Rafiei
Birjand University of Medical Sciences
Outcome results
None listed