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Effects of three anesthetics on intraoperative bleeding and postoperative pain

Comparison of local anesthesia induced by diphenhydramine, lidocaine 1%, and normal saline on postoperative pain and intraoperative blood loss in nasal fracture reduction surgery

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170316033099N1
Enrollment
108
Registered
2018-10-09
Start date
2018-09-25
Completion date
Unknown
Last updated
2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasal fracture. Fracture of nasal bones

Interventions

Intervention 1: Intervention group 1 (lidocaine 1%): The members of this group place cotton pieces soaked in lidocaine 1% in their nostrils 20 minutes before surgery. Intervention 2: Intervention grou

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 50 Years

Inclusion criteria

Inclusion criteria: Signing informed consent age between 6 and 50 years nasal fracture

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Bladder disease Known allergic reactions to antihistamines, benzodiazepines, or topical anesthetics Open nasal fracture reduction or concurrent surgery on the nose septum Any coagulation disorder or excessive pain

Design outcomes

Primary

MeasureTime frame
Postoperative pain. Timepoint: 0, 6, and 24 hours after the operation. Method of measurement: Visual analog scale.;The amount of intraoperative blood loss. Timepoint: After operation. Method of measurement: The amount of blood suctioned; the number of gauzes and long gauzes used; the amount of blood in the surgery field, on the surgery drape, and in the drain.

Secondary

MeasureTime frame
Systolic and diastolic blood pressure. Timepoint: At admission, two times during the operation, one time before the patient leaves the recovery room. Method of measurement: sphygmomanometer and monitoring device (Sa'adat Company).;Heart rate. Timepoint: before and after the operation. Method of measurement: monitoring device (Sa'adat Company).;Hemoglobin and hematocrit levels. Timepoint: before and after surgery. Method of measurement: laboratory.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Ramezani

Birjand University of Medical Sciences

Mahmud.kaveh@gmail.com+98 56 3239 5641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026