Myocardial heart. Myocardial degeneration
Conditions
Interventions
Intervention 1: four to twelve hours before surgery given to patients cyclosporine capsules orally at a dose of 2.5 mg per kg for a single Dose under normal conditions and maitain general anesthesia
Treatment - Drugs
Four to twelve hours before surgery to patients given placebo orally All stages of operation under normal conditions and maintain general anesthesia and monitoring blood pressure and electrocardio
four to twelve hours before surgery given to patients cyclosporine capsules orally at a dose of 2.5 mg per kg for a single Dose under normal conditions and maitain general anesthesia and monitoring
Sponsors
Vice Chancellor for Research and Technology Development Jundishapur University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: - All patients who undergoing coronary artery bypass surgery . - Patients over 18 years - willingness to participate in the study Exclusion criteria - patients over 85 years - patients with unstable angina - Patients with moderate to severe renal impairment (glomerular filtration rate less than mL / min / m2 45) - developing cirrhosis of the liver - Oral administration of drugs glibenclamide or nicorandil (due to drug interactions).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin_I. Timepoint: Troponin I measurements before surgery and at 24hr, 48hr and 72hr after surgery. Method of measurement: After preparing the evaluation kit little troponin (cTnI) by Golestan hospital laboratory. | — |
Secondary
| Measure | Time frame |
|---|---|
| CKMB. Timepoint: CKMB measurements before surgery and at 24hr, 48hr and 72hr after surgery. Method of measurement: CKMB measurements in the laboratory Golestan Hospital. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad hassan Adel
Ahwaz JundiShapur University of Medical Sciences
Outcome results
None listed