Frontotemporal dementia. Frontotemporal dementia
Conditions
Interventions
Intervention group: inflawell receiving group, 3 month, 3 times/day, oral administration (400 mg), inflawell containing Boswellic acids powders was manufactured in KondorPharma pharmaceutical Company
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Behavioral variant of Frontotemporal dementia based on guideline: Rascovsky K, Hodges JR, Knopman D, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134 Language variant of Frontotemporal dementia based on guideline: Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76:1006-1014
Exclusion criteria
Exclusion criteria: Other specific diseases of the central nervous system such as Parkinson's, multifactorial dementia, anterior brain dementia, Huntington's disease, hydrocephalus, brain tumors confirmed by MRI, severe paralysis of the nerve of the supernuclear body, epilepsy, clots between layers of brain tissue, multiple sclerosis and other dementias Taking NSAIDs and systemic corticosteroids for previous two months continuously Severe cardiovascular disease, kidney and liver disorders Psychiatric disorders include bipolar disorder and schizophrenia under medication Drugs or alcohol abuse Brain-related surgical interventions head trauma and progressive degenerative motor disorder Metabolic and systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the lesion area of brain. Timepoint: At the commencement of the investigation and 3 months after taking inflawell. Method of measurement: MRI ( Diffusion Tensor Imaging). | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cognitive and behavioral symptoms. Timepoint: At the commencement of the investigation and 3 months after taking inflawell. Method of measurement: Clinical cognitive tests: Behavioral inventory and FTD-Clinical dementia rating (FTD-CDR), Neuropsychiatry inventory (NPI), Frontal assessment buttery (FAB), Persian naming test (PNT). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactVajihe Aghamolie
Tehran University of Medical Sciences
Outcome results
None listed