Female infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group 1: Patients (n=27) treated with clomiphene (2 tablets of 50 mg, daily for 5 days) from the third day of menstruation along with the start of gonadotropin until the t
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Individuals with poor response (age =40 years or antral follicle count (AFC ) <3 in each ovary or poor response in the previous cycle) and without any uncontrolled underlying cardiac, hepatic, or renal disease, as well as normal male factor, thyroid, and prolactin levels will be included in the study.
Exclusion criteria
Exclusion criteria: Ovarian failure and cycle cancellation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Metaphase II oocytes. Timepoint: Post-intervention (10-12) days after the start of the intervention and ovarian stimulation (at the time of oocyte retrieval ). Method of measurement: Number of oocyte (MII) after oocyte retrieval by embryologist.;Number of embryos formed and their grade. Timepoint: Number of embryo after oocyte retrieval by embryologist. Method of measurement: Number of embryos formed and their grade (according to the Gardner embryo grading system). | — |
Secondary
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate. Timepoint: Two weeks after embryo transfer. Method of measurement: Pregnancy test.;Clinical pregnancy rate. Timepoint: five weeks after embryo transfer. Method of measurement: Sonography.;Implantation rate. Timepoint: five weeks after embryo transfer. Method of measurement: Sonography.;Early miscarriage and late miscarriage. Timepoint: Before12weeksand 12-20 weeks. Method of measurement: Bleeding and expulsion of the fetus.;Multiple pregnancy rate. Timepoint: five weeks after embryo transfer. Method of measurement: Sonography.;Ongoing pregnancy. Timepoint: 12 weeks. Method of measurement: Sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMalihe Afiat
Mashhad University of Medical Sciences
Outcome results
None listed