Comparison of stair-step Letrozole alone with Letrozole and gonadotropins combination for ovulation induction of PCOS infertile women resistant to Letrozol and candidate for IUI

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170315033085N6

Enrollment

Registered

2021-04-28

Start date

2021-05-12

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility, unspecified

Interventions

Intervention 1: Control group: In this group, letrozole will be used for treatment from the second day of the cycle at a dose of 5 mg daily for 5 days in addition to Cinnal-f® (75 mcg subcutaneous) o

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women with polycystic ovary syndrome according to Rotterdam criteria Need for ovulation induction Normal uterus and uterine tubes function (having at least one open fallopian tube using HSG) Normal results of the spouse's Spermograms along with normal results for thyroid and prolactin tests

Exclusion criteria

Exclusion criteria: Any genetic or psychological disorders Progressive liver, kidney or cardiovascular disorders

Design outcomes

Primary

Measure	Time frame
Number of dominant follicles. Timepoint: Day 14 of the cycle. Method of measurement: Transvaginal ultrasound.;Endometrial thickness. Timepoint: Day 14 of the cycle. Method of measurement: Transvaginal ultrasound.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMalihe Afiat

Mashhad University of Medical Sciences

afiatm@mums.ac.ir+98 51 3802 2608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026