Wound. Open wound of unspecified body region
Conditions
Interventions
Intervention 1: Intervention group: Wound covering of donor site of skin transplantation with amniotic membrane extract drops. From the day of surgery, dressing is changed every 3 days until complete
Treatment - Drugs
Intervention group: Wound covering of donor site of skin transplantation with amniotic membrane extract drops. From the day of surgery, dressing is changed every 3 days until complete wound healing
Control group: Wound covering of donor site of skin transplantation with solvent amniotic membrane extract drops (normal saline). From the day of surgery, dressing is changed every 3 days until comple
Sponsors
Iran University of Medical Sciences
Added at 2017-08-20: Royan Institute for Stem Cell Biology and Technology (RI-SCBT
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 18-65 years old; requiring skin graft surgery; signing informed consent. Exclusion criteria: removal of skin graft from the outside of the thigh; conditions and diseases in which the immune system is weakened and wound healing is delayed such as: diabetes, cancer, immune system dysfunction, drugs that suppress the immune system, taking corticosteroids, smoking and alcohol; patients who do not cooperate with treatment and referrals necessary after surgery.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound Healing. Timepoint: Observation, examination and photography on days 1 and 12 after surgery and during spontaneous separation of Vaseline gauze from wound. Method of measurement: Observation, examination and photography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost. Timepoint: The end of the study. Method of measurement: Cost estimation of the number of drops used in each treatment group.;Scar. Timepoint: 6 months after surgery. Method of measurement: Vancouver Scar Scale, Patient and Observer Scar Assessment Scale (POSAS).;Infection. Timepoint: Every 3 days after surgery until complete wound healing. Method of measurement: Observation, examination and wound culture.;Pain. Timepoint: 3, 6 and 12 days after surgery. Method of measurement: Visual Analogue Scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTooran Bagheri
Burn Research Center
Outcome results
None listed