Effect of Magnesium sulfate, Ondansetron, Metoclopramide and Low dose of propofol on pain reduction due to propofol injection in gynecologic surgeries

comparing the effects of premedication of magnesium sulfate, ondansetron, metoclopramide and low dose of propofol on pain reduction due to propofol injection in gynecologic surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017031433069N1

Enrollment

120

Registered

2017-09-29

Start date

2017-04-04

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induced pain. Complications following infusion, transfusion and therapeutic injection

Interventions

Intervention 1: Administration of Magnesium sulfate (30 milligram per kilogram) to prevent the propofol injection pain. Intervention 2: Administration of Metoclopramide (10 milligram) to prevent the

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Female patients 18-45 years old ASA I, II candidate for elective gynecological surgery under general anesthesia

Exclusion criteria

Exclusion criteria: History of soy and egg allergy any contraindications for the drugs in the study neurological-psychological diseases addiction, use of sedatives and analgesics in the 24 hours before surgery chronic pain syndromes need for rapid anesthesia induction Lack of proper veins for injecting the drugs difficulty in communicating.

Design outcomes

Primary

Measure	Time frame
Pain severity due to propofol injection. Timepoint: Once after injection of one fourth of induction dose (0.25 milligram per kilogram) of propofol. Method of measurement: McCrirrick and Hunter scale: None (0): No complaint of pain after asking/ Mild (1): Pain reported after asking, without any behavioral signs/ Moderate (2): Pain reported after asking, accompanied by behavioral signs or pain reported without asking/ Severe (3): Strong vocal response or response accompanied by facial grimacing, arm withdrawal or tears.	—

Measure

Time frame

Pain severity due to propofol injection. Timepoint: Once after injection of one fourth of induction dose (0.25 milligram per kilogram) of propofol. Method of measurement: McCrirrick and Hunter scale: None (0): No complaint of pain after asking/ Mild (1): Pain reported after asking, without any behavioral signs/ Moderate (2): Pain reported after asking, accompanied by behavioral signs or pain reported without asking/ Severe (3): Strong vocal response or response accompanied by facial grimacing, arm withdrawal or tears.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Gelareh Biazar

Alzahra Hospital

gelarehbiazar1386@gmail.com+98 13 3332 9524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026