To evaluate the efficacy of clonidine and tramadol in preventing post spinal anesthesia shivering

A comparison of two oral drugs clonidine and tramadol on post spinal shivering anesthesia in patients undergoing transureteral lithotripsy (TUL) referred to Shahid Hashemi Nejad hospital in 2016-2017

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017031432017N2

Enrollment

Registered

2017-05-20

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothermy due to anaesthesia. Hypothermy due to anaesthesia

Interventions

Intervention 1: The first intervention group oral Clonidine 100 with 50 cc of water 90 minutes before spinal anesthesia. Intervention 2: Second intervention group Tramadol tablets 50 mg orally with

Treatment - Drugs

The first intervention group oral Clonidine 100 with 50 cc of water 90 minutes before spinal anesthesia

Second intervention group Tramadol tablets 50 mg orally with 50 cc of water 90 minutes before spinal anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA 1 and 2 patients who underwent spinal anesthesia for elective TUL. Patients who consent to have spinal anesthesia without any local or general infection, heart disease, bradycardia or left ventricular disfunction, kidney, liver disease, seizures, coagulopathy. Patients with BMI <30 with any history of sensitivity or allergy to clonidine and tramadol or history of addiction. Exclusion criteria: Patients who fail their spinal anesthesia or their spinal anesthesia being off during surgery and underwent general anesthesia or are not satisfied to participate in the study for any reason.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Peripheral temprature. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Digital thermometer in Centigrade from forehead.;Core temprature. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Digital thermometer in Centigrade from tympanic membrane erea.;Blood pressure. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: NIBP with digital monitoring in operation room.;Heart rate. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: With digital monitoring in operation room.;Shivering. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Seeing based on Mahajan category.	—

Measure

Time frame

Peripheral temprature. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Digital thermometer in Centigrade from forehead.;Core temprature. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Digital thermometer in Centigrade from tympanic membrane erea.;Blood pressure. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: NIBP with digital monitoring in operation room.;Heart rate. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: With digital monitoring in operation room.;Shivering. Timepoint: Every 10 minutes up to 120 min later. Method of measurement: Seeing based on Mahajan category.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahmood Reza Mohaghegh

Iran University of Medical Sciences

mohaghegh_mr@yahoo.com; mohaghegh.mr@moheb.com+98 21 81161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026