Brain metastasis. Malignant neoplasm of brain
Conditions
Interventions
Intervention 1: Intervention group: whole brain radiation with 30 Gray in 10 fractions and using 25 mg losartan tablet during radition course. Intervention 2: Control group: standard treatment with wh
Sponsors
Ahvaz Jundi Shapour university of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Extracranial metastasis confirmed by pathology MRI imaging suggestive for brain metastasias with at least 1 cm in size Predicted survival at least 8 weeks for patient Zubrud performance scale 0, 1, 2, 3 Absolout neutrophil count>1000 in mm3 Serum platlet >50000 in mm3 Serum Cratinin< 1.5 mg/d BUN<25 in dl Serum potassium 3.5-5 mmol/L Get informed consent
Exclusion criteria
Exclusion criteria: ?Sever mental or physical illness disturbing treatment according protocole Previous brain radiotherapy or radiosurgery Patients wihtout regular follow-up Age90 years Previous treatment with ACEI/ARB drugs Pregnancy Baseline hypotenssion Leptomeningeal involvment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiologic response of brain metastatic lesion. Timepoint: 6 weeks after ending of intervention. Method of measurement: RECIST V1.1criteria for response evaluation in solid tumors. | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiologic response of non target metastatic brain lesion. Timepoint: 6 weeks after ending intervention. Method of measurement: RECIST v 1.1 criteria for response evaluation in solid tumors. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactYasamin Mahouram
Ahvaz Jundishapour University Of Medical Science
Outcome results
None listed