The effect of vitamin C on reducing bleeding and its consequences in myomectomy surgery. Other specified conditions associated with female genital organs and menstrual cycle
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, half an hour before the myomectomy, the patients will receive 2 grams of vitamin C manufactured by Osweh pharmaceutical company during in
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: symptomatic myomas without response to medical treatments (laparotomy, infertility for more than 3 years with myomectomy indication), pelvic pain and pressure, frequent urination and constipation) uterus size less than 18 weeks not accepting hysterectomy Myoma grade 2-6 based on ultrasound the cause of myoma bleeding has been diagnosed patients with symptomatic myoma candidates for myomectomy
Exclusion criteria
Exclusion criteria: Lack of consent to participate in research women with multiple myomas use of tricyclic antidepressants and monoamine oxidase inhibitors Patients with liver diseases, ischemic heart disease, cardiomyopathy, diabetes, asthma, COPD, recurrent vascular thrombosis and malignancy, G6PD deficiency, history of oxalate stones, coagulation problems, seizures, uncontrolled hypertension, hyperthyroidism. A history of oxalate stones and a serum creatinine level >1.5 mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occult bleeding. Timepoint: before and 4 hours after the patient's operation. Method of measurement: Occult bleeding (HBL) is the difference between overt bleeding and the amount of bleeding calculated based on changes in hemoglobin (HB) before and after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: During surgery. Method of measurement: Monitoring Device Register.;Mean arterial pressure. Timepoint: During surgery. Method of measurement: Monitoring Device Register. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Gelareh Biazar
Rasht University of Medical Sciences
Outcome results
None listed