The effect of lidocaine on wakefulness during general anesthesia in elective cesarean section

Investigating the effect of intravenous lidocaine on awareness during elective cesarean section under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170314033069N7

Enrollment

Registered

2023-09-12

Start date

2023-09-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of intravenous lidocaine on awareness during general anesthesia for elective cesarean section. Other symptoms and signs involving cognitive functions and awareness

Interventions

Intervention 1: Intervention group: In the lidocaine group, before induction of anesthesia, 1 milligram per kilogram intravenous lidocaine 2% (100 milligram/5 milliliter, Aburaihan Pharmaceutical Comp

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Pregnant women candidates for caesarean section surgery under general anesthesia American Society of Anesthesiologists (ASA) II, I Hemodynamically stable condition

Exclusion criteria

Exclusion criteria: Inability to communicate appropriately verbally to fill out the questionnaire sensitivity to local amide acetic acid Any contraindications to the use of ondansetron (heart problems, especially Long Q-T) Contraindications to Apotel (liver failure) Contraindications to propofol (including drug-food allergies) Contraindications to lidocaine, including heart blocks (bradydysrhythmias) The presence of any psychiatric disorder that interferes with answering the questions. A history of malignant hyperthermia that prohibits the use of inhaled gases and succinylcholine.

Design outcomes

Primary

Measure	Time frame
The effectiveness of lidocaine on the frequency of different states of the first memory after regaining consciousness. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.;The effectiveness of lidocaine on the frequency of different states of the last memory before anesthesia of patients. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.;The effectiveness of lidocaine on the frequency of different conditions related to awareness during anesthesia. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.	—

Measure

Time frame

The effectiveness of lidocaine on the frequency of different states of the first memory after regaining consciousness. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.;The effectiveness of lidocaine on the frequency of different states of the last memory before anesthesia of patients. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.;The effectiveness of lidocaine on the frequency of different conditions related to awareness during anesthesia. Timepoint: 24 hours after surgery. Method of measurement: Face-to-face interview.

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Secondary

Measure	Time frame
The effect of lidocaine on hemodynamic changes of patients (mean blood pressure and heart rate of the patient). Timepoint: 4 stations: base time (before injection of lidocaine), after intubation, end of operation, and after extubation. Method of measurement: Blood pressure and heart rate monitoring of patients.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Gelareh Biazar

Rasht University of Medical Sciences

gelarehbiazar1386@gmail.com+98 13 3332 9524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026