Comparison the effect of Progestrone and Nifedipine in prevention of preterm delivery

Comparsion of Progestrone and Nifedipine in treatment of preterm delivery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017031133016N1

Enrollment

Registered

2017-04-03

Start date

2016-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm delivery. Preterm labour and delivery

Interventions

Intervention 1: Second group: administration of 50 miligram progesterone intramascular injection once daily for 48 houres. Intervention 2: First group: administration of 100 miligram nifedipine every

Treatment - Drugs

Second group: administration of 50 miligram progesterone intramascular injection once daily for 48 houres

First group: administration of 100 miligram nifedipine every 8 houre for 48 houres

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Main exclusion criteria: diabetes; hypertension; seizure; migraine; heart disease; kidney disease; asthma; active liver disease; thrombophlebitis; cervix insufficiency; twins and more pregnancy; cervical dilation = 4 cm; intrauterine growth retardation; PROM; vaginal bleeding; tocolysis contraindications include fetal distress, chorioamnionitis, severe preeclampsia, hemodynamic instability; trauma history; smoking; history of taking cimetidine, beta blockers, digoxin or nitrates

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Reduction of uterine contractions. Timepoint: Every 20 minutes after the treatment start. Method of measurement: Manual by.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzam Sheikhi

Zahedan University of Medical Sciences

Dr.sheikhi@zaums.ac.ir+98 54 3322 4991

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026