Depression. Major depressive disorder, recurrent, moderate
Conditions
Interventions
Intervention 1: Intervention group: harmala alkaloids: Extraction is performed through routine methods for alkaloids extraction. Then a semi-automatic capsule filler was used to fill the harmaline cap
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ability to read, understating and sign the informed consent form and the study procedures male or female aged 18–65 years without any previous diagnosis of other mental disorders such as bipolar disorder, psychosis, primary anxiety disorder, and substance abuse or dependence disorder reporting the Hamilton Depression Rating Score (HAMD) score above 14 agreed to use suitable family planning methods during the study and three months afterward non-smoking not being pregnant under only SSRIs antidepressant regimen
Exclusion criteria
Exclusion criteria: they have a current diagnosis of other mental disorders including bipolar disorder, psychosis, primary anxiety disorder, and substance abuse or dependence disorder pregnancy and breastfeeding taking antidepressant except for SSRIs, mood stabilizer, or antipsychotic drug chemotherapy or other medications known to produce mood changes sensitivity to harmala alkaloids emerging serious adverse effects with the alkaloids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anhedonia, depressed mood, change in appetite, sleep, and suicidal ideations. Timepoint: Week 0, 4 and 6. Method of measurement: Hamilton Depression Rating Scale score.;Depression. Timepoint: Week 0, 4 and 6. Method of measurement: Beck Depression Inventory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Razmi
Iranian academic center for education culture and research
Outcome results
None listed