Effect of Ibuprofen and Novafen on pain relief after endodontic treatment

Comparison of prophylactic effect of Ibuprofen and Novafen with placebo on pain relief in patients requiring endodontic treatment

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017031032984N1

Enrollment

Registered

2017-07-01

Start date

2017-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Relation of prophylactic effect of Ibuprofen and Novafen on pain relief after endodontic treatment.

Interventions

Intervention 1: Novafen, capsule 200 mg oral, once, 1 hour before root canal therapy. Intervention 2: Ibuprofen, capsule 400 mg oral, once, 1 hour before root canal therapy. Intervention 3: Placebo, c

Treatment - Drugs

Placebo

Novafen, capsule 200 mg oral, once, 1 hour before root canal therapy

Ibuprofen, capsule 400 mg oral, once, 1 hour before root canal therapy

Placebo, capsule oral, once, 1 hour before root canal therapy

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria: Age range of 18 to 65 years old; having teeth with alive pulps and no periapical lesion; moderate to severe dental pain at reception (VAS>4) The exclusion criteria: Pregnancy; lactation; history of allergy to NSAID or sulfonamides; history of asthma; chronic use of analgesic; alcohol consumption; having systemic diseases; having cancer or severe abnormalities; use of any analgesic during 12 hours before starting intervention; current smoker

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of dental Pain. Timepoint: Before treatment, 6 hour after treatment, 12 hour after treatment, 24 hour after treatment, 48 hour after treatment. Method of measurement: Visual Analog Scale.	—

Secondary

Measure	Time frame
Number of analgesic used. Timepoint: 24 hour after treatment, 48 hour after treatment. Method of measurement: Patients report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtieh sadat Rezaei

Qom University of Medical Sciences

amir.sad313@gmail.com+98 25 3612 2053

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026