Assement of dental supporting tissue Inflammation during orthodontic treatment

Comparison of canine pre-inflammatory cytokines changes after applying the distaizing force to the opposite side of canine control teeth in patients who have extracted maxillary first premolars teeth and undergoing orthodontic treatment

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017030632903N2

Enrollment

Registered

2017-10-02

Start date

2017-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

proinflammatory cytokines. Fitting and adjustment of orthodontic device

Interventions

Intervention 1: one week after extraction of maxillary first premolars and right before the bonding of orthodontic attachments, baseline GCF (T0) will be collected at the mesial and distal sites of co

one week after extraction of maxillary first premolars and right before the bonding of orthodontic attachments, baseline GCF (T0) will be collected at the mesial and distal sites of control teeth usin

one week after extraction of maxillary first premolars and right before the bonding of orthodontic attachments, baseline GCF (T0) will be collected at the mesial and distal sites of test teeth using

Eligibility

Sex/Gender

All

Age

10 Years to 21 Years

Inclusion criteria

Inclusion criteria: inclusion criteria are as follows: requiring extraction of maxillary first premolars and distalization of maxillary canine teeth by fixed orthodontic treatment; systemic health; no current smoking or tobacco use; no intake of antibiotics, immunosuppressants, drugs changing the hormonal balance such as contraceptives, antihistamines or non-steroidal anti-inflammatory drugs in the past four months (prior to study onset); no radiographic evidence of alveolar bone loss. The exclusion criteria are current smoking or tobacco use and intake of immunosuppressants, hormonal medications, antihistamines or non-steroidal anti-inflammatory drugs.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Proinflammatory cytokines. Timepoint: before beginning of orthodontic treatment -after1 houer and 28 day following force application. Method of measurement: ELISA analyse.	—

Secondary

Measure	Time frame
Time. Timepoint: prior to orthodontic force application (T0), one hour after orthodontic force application (T1) and 28 days after force application (T2). Method of measurement: houer and day.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Hashemi Habibabadi

Zahedan Dental School University

roya.3816@yahoo.com+98 54 3344 1824

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 5, 2026