Knee Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group 1: manual acupuncture group. In this group, acupuncture needles of specific size are used in predetermined and identical points and are stimulated by hand every ten
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with knee OA based on ACR criteria (ACR=American college of Rheumatology )( OA=Osteoarthritis ) Age should be between 45 and 65 years old Only one knee is involved Have a VAS pain score of four or more than four.(VAS=visual Analogue scale ) Be literate (writing and reading ability)
Exclusion criteria
Exclusion criteria: The surgery has been detailed or is in the process of surgery Knee arthroscopy has been done during the last year Have an intra-articular injection during the last six months Any disease that disrupts the functioning of the immune system, such as inflammatory diseases, autoimmune diseases, connective tissue diseases, diabetes, cancer, etc. Severe physical or cognitive illness of the participant that prevents the continuation of cooperation Have a pacemaker Pregnancy and breastfeeding Have done acupuncture during the last six months Coagulation disorders and the use of anticoagulants Participation of the candidate in other clinical studies currently or during the last three months Getting infected with covid during the study or ... in the last month or other infectious diseases during the struggle . BMI more than 30 (BMI =body mass index ) Any forced changes in treatment regimen Non-cooperation in applying intervention for more than two sessions If the joint has liquid effusion (joint effusion) Life-threatening medical and clinical events Extreme fear of needles( Belonephebia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome 1) changes in the level of pain based on the VAS scale before the intervention and weeks 8, 12, and 16.--- . 2) Measuring the amount of inflammatory factors: including IFN-? (gama interferon )secreted by T-helper1 cells, IL-4 ( interleukin-4 ) secreted by T-helper-2 cells. -- and TGF-ß ( transforming growth factor beta ) and IL10 ( interleukin 10 )secreted by regulatory T cells (T REG CELLS), and TNFa (tumor necrosis factor alpha )secreted by M1 macrophages before and after treatment at the end of weeks 8 . Timepoint: 0-8-12-16 weeks. Method of measurement: Based on numerical scale of vas and based on laboratory numerical values. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the level of physical activity. Timepoint: Before intervention and weeks 8, 12 and 16. Method of measurement: WOMAC Scale( Western Ontario McMaster Universities Osteoarthritis Index).;Changes in morning stiffness. Timepoint: Before intervention and weeks 8, 12 and 16. Method of measurement: WOMAC Scale.;Changes in quality of life. Timepoint: Before intervention and weeks 8, 12 and 16. Method of measurement: Based on the quality of life form (QoL ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contact?Ahmad Hamzeh
Mashhad University of Medical Sciences
Outcome results
None listed