The effect of vitamin D in the prevention of MS disease in first degree relatives of MS patients.

The effect of vitamin D supplementation on the gene expression of interleukins 10, 17A and 6 in the apparently healthy first degree relatives of multiple sclerosis patients compared to apparently healthy people.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201703033655N3

Enrollment

Registered

2017-03-28

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: Control group: supplement therapy by vitamin D for 8 weeks, 50000 IU/week. Intervention 2: Intervention group: supplement therapy by vitamin D for 8 weeks, 50000 IU/week.

Prevention

Control group: supplement therapy by vitamin D for 8 weeks, 50000 IU/week.

Intervention group: supplement therapy by vitamin D for 8 weeks, 50000 IU/week.

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria :the ability to give blood sample; tendency to take part in the study and filling FFQ and food record forms; having 20-40 years old. Exclusion criteria: having malabsorption; consumption of medicine that interact with Vitamin D absorption; catching chronic and immune system diseases; consumption of Ca & Vitamin D supplementation; pregnancy and lactation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Interleukin 10. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;Interleukin 17A. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;Interleukin 6. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;25- hydroxy vitamin D level. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Electro Chemiluminescence.	—

Measure

Time frame

Interleukin 10. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;Interleukin 17A. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;Interleukin 6. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Real Time-PCR.;25- hydroxy vitamin D level. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Electro Chemiluminescence.

—

Secondary

Measure	Time frame
Creatinine serum. Timepoint: twice: before and after intervention (after 2 months). Method of measurement: by Enzymatic Method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Syed Rafie Aref Hosseini

Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences

srarefhosseini@gmail.com+98 41333575813

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026