Effect of green tea pills and metformin versus placebo on ovulation, menstrual regulation and anti-oxidative biomarkers in women with polycystic ovarian syndrome

Effect of green tea pills and metformin versus placebo on ovulation, menstrual regulation and anti-oxidative biomarkers in women with polycystic ovarian syndrome: a single blind controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201703029014N148

Enrollment

120

Registered

2017-03-09

Start date

2016-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group 1: Green tea pill 3 times a day for 3 months. Intervention 2: Intervention group 2: Metformin tablet 500 mg 3 times a day for 3 months. Intervention 3: Control group

Treatment - Drugs

Intervention group 1: Green tea pill 3 times a day for 3 months.

Intervention group 2: Metformin tablet 500 mg 3 times a day for 3 months

Control group: Placebo tablet 3 times a day for 3 months.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 40 years; polycystic ovarian syndrome; insulin resistance; body mass index >25; oligoovulation; Irregular menstruation. Exclusion criteria: Cardiovascular diseases; renal failure; mental disorder; hyperthyroidisms; gastric problem; sensitivity to caffeine; using warfarin, aspirin; propranolol or alkaline phosphatase.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Ovulation. Timepoint: before intervention and 3 months after intervention. Method of measurement: by sonography.;Menstrual regulation. Timepoint: before intervention and 3 months after intervention. Method of measurement: by history taking.;Measurement of anti-oxidative biomarkers. Timepoint: before intervention and 3 months after intervention. Method of measurement: through laboratory evaluation.	—

Measure

Time frame

Ovulation. Timepoint: before intervention and 3 months after intervention. Method of measurement: by sonography.;Menstrual regulation. Timepoint: before intervention and 3 months after intervention. Method of measurement: by history taking.;Measurement of anti-oxidative biomarkers. Timepoint: before intervention and 3 months after intervention. Method of measurement: through laboratory evaluation.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mahnaz Yavangi

Fatemieh Hospital

m_yavangui@yahoo.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026