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Comparison of the effect of Ketamine and Dexamethasone in combination with Lidocaine on the onset and duration of Axillary block in soft tissue surgery of forearm and hand

Comparison of the effect of Ketamine and Dexamethasone in combination with Lidocaine on the onset and duration of Axillary block in soft tissue surgery of forearm and hand

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017030132837N1
Enrollment
78
Registered
2017-04-20
Start date
2016-12-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Soft tissue injury of forearm and hand. Superficial injury of forearm, Open wound of forearm, Injury of nerves at forearm level,Injury of blood vessels at forearm level, Injury of muscle and tendon at forearm level, Superficial injury of wrist and hand, Open wound of wrist and hand, Injury of

Interventions

Intervention 1: The intervention group 1 : Axillary block with 38 cc lidocaine 1% in combination with dexamethasone 8 mg in 2 ml. Intervention 2: The intervention group 2 : Axillary block with 38 c
The intervention group 1 : Axillary block with 38 cc lidocaine 1% in combination with dexamethasone 8 mg in 2 ml
The intervention group 2 : Axillary block with 38 cc Lidocaine 1% combination with 50 mg of Ketamine in 2 cc
Control group : Axillary block with 38 cc lidocaine 1% in combination with 2 mL of saline

Sponsors

Vice chanceler for research, Iran university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Consent to participate in research project and cooperation for axillary block; No addiction to opium, Benzodiazepine, Clonidine; Absence of liver and kidney failure, diabetes, cardiovascular and lung diseases, coagulopathy; Lack of any allergic history to local anesthetics; No use of opium in the past 48 hours; Absence of anatomical deformity or burning or infection in block region; No pregnancy in female patients. Exclusion criteria: The unwillingness or lack of cooperation from the patient during surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Onset of sensory block. Timepoint: every 3 minutes. Method of measurement: Measuring the length of time between the last injection until complete disappearance of any sense of touch with the stopwatch.;Onset of motor block. Timepoint: every 3 minutes. Method of measurement: Measuring the length of time between the last injection to complete motor paralysis with Stopwatch.;Duration of sensory block. Timepoint: every 3 minutes. Method of measurement: Measuring the time between onset of complete sensory block until the complete return again sense organs with Stopwatch.;Duration of motor block. Timepoint: every 3 minutes. Method of measurement: Measuring the time between onset of complete paralysis to return of complete movement power with stopwtch.

Secondary

MeasureTime frame
Diastolic blood pressure. Timepoint: 0, 5, 10, 15, 20, 25 minutes after Axillary block. Method of measurement: Non-invasive automatic sphygmomanometer.;Systolic blood pressure. Timepoint: 0, 5, 10, 15, 20, 25 minutes after Axillary block. Method of measurement: Non-invasive automatic sphygmomanometer.;Pulse rate. Timepoint: 0, 5, 10, 15, 20, 25 minutes after Axillary block. Method of measurement: ECG monitoring.;Nystagmus. Timepoint: 0, 5, 10, 15, 20, 25 minutes after Axillary block. Method of measurement: Find the rapid movements of the eyes of horizontal reciprocating.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Behrooz Zaman

Hazrat Fatemeh Hospital

behroozzaman@gmail.com zaman.b@iums.ac.ir+98 21 8871 0099

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026