Effect of Crocin on patient with open angle glaucoma

Study of the effect of Crocin on patient with open angle glaucoma by double blinded, randomized and placebo-controlled clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017030113058N6

Enrollment

Registered

2017-09-17

Start date

2017-04-09

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary open-angle glaucoma. Primary open-angle glaucoma

Interventions

Intervention 1: Treatment Group: Patients with open angle glaucoma that used 15 mg per day of crocin tablet with the routine treatment of open-angle glaucoma drug. Crocin is a full herbal medicine con

Treatment - Drugs

Treatment Group: Patients with open angle glaucoma that used 15 mg per day of crocin tablet with the routine treatment of open-angle glaucoma drug. Crocin is a full herbal medicine constitute of saffr

Control group: Patients with open angle glaucoma that used one placebo tablet per day with routine drugs of glaucoma.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients (40 years and older) with open angle glaucoma; The ability to understand the generalities of study,Interventions and possible complications; Eye pressure (IOP) above 21 with or without treatment; cup-to-disc ratio =0.4>0.8; Similarity of glaucoma intensity in two eyes. Exclusion criteria: The presence of eye disease and the use of steroids that can affect eye pressure; History of intraocular surgery and laser therapy; Pregnancy and breastfeeding; Saffron sensitivity; Advanced glaucoma at the bedside, based on prime criteria (It is done for all patients with glaucoma routinely).

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
??Side effects of crocin. Timepoint: Before intervention, and two and four months later. Method of measurement: Questionnaire for side effect of crocin.	—

Primary

Measure	Time frame
Intraocular Pressure. Timepoint: Two months before and two months after treatments. Method of measurement: Tonometer.;Retinal nerve fiber layer. Timepoint: Before the intervention and at the end of month 2 and 4 months later. Method of measurement: RNFL OCT.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Ahmad Mohajeri

Mashhad University of Medical Sciences

mohajeria@mums.ac.ir+98 51 3882 3251

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026