Pain caused by propofol injection. Adverse effect of intravenous anesthetics
Conditions
Interventions
Intervention 1: Control group: After IV catheterizationin the patient's hand, 5 cc blood samples are taken to measure the serum level of complement factor C3. One minute later fentanyl 3 micg/kg and m
Prevention
Control group: After IV catheterizationin the patient's hand, 5 cc blood samples are taken to measure the serum level of complement factor C3. One minute later fentanyl 3 micg/kg and midazolam 0.15 mg
Intervention group 1: After intravenous catheterization, 5 cc blood samples are taken to measure the serum level of complement factor C3.Then propofol infusion 50µg/kg/min ( Manufactured by: Freseniu
Intervention group 2: After intravenous catheterization, 5 cc blood samples are taken to measure the serum level of complement factor C3.Then propofol infusion 100µg/kg/min ( Manufactured by: Freseniu
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients are candidates for general anesthesia ASA I & II
Exclusion criteria
Exclusion criteria: uncontrolled chronic and acute diseases age >60 age<18 history of hypersensitivity to drugs and foods History of using NSAIDS and corticostroides opioid addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: At the time of the intervention. Method of measurement: visual analogue scale of pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in serum level of complement factor C3. Timepoint: Immediately before the intervention and two minutes after the intervention. Method of measurement: Blood sampling and laboratory measurements. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehrooz Zaman
Iran University of Medical Sciences
Outcome results
None listed