Induction of labor with 3 different methods.

A comparison between induction of labor with 3 methods of titrated oral misoprostol, constant dose of oral misoprostol and folly catheter with extra amniotic saline infusion (EASI), in women with unfavorable cervix.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201702282624N22

Enrollment

116

Registered

2017-04-03

Start date

2014-04-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Delivery. Condition 2: Outcome of delivery. Pregnancy, childbirth and the puerperium Outcome of delivery

Interventions

Intervention 1: In oral titrared misoprostol group: 200µg misoprostol tablet will be solved in 200 milliliter of water (this solution is stable in the room temperature and contains 1µg misoprostol in

Treatment - Drugs

In oral titrared misoprostol group: 200µg misoprostol tablet will be solved in 200 milliliter of water (this solution is stable in the room temperature and contains 1µg misoprostol in 1mlit of soluti

In oral misoprostol group, 50µg misoprostol will be administered and women will be followed up to 4 hours. FHR and uterine contractions will be checked hourly. In the cases of not having suitable con

In the EASI group, folly catheter of number 18 was introduced through cervical canal and was filled with 30mlit distilled water and was fixed above the internal cervical OS, and was connected to norma

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : maternal age between 18-40 years old; gestational age of more than 37 weeks ; singleton, cephalic presentation, intact membrane and Bishop Score of less than 6. Exclusion criteria : any sign of fetal distress; placenta previa and any vaginal bleeding of more than bloody show; history of any surgery on uterus including cesarean section; known uterine anomaly; intra uterine fetal death, and known hypersensitivity to misoprostol.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Delivery during the first 24 hours after intervention. Timepoint: 24 hours. Method of measurement: Data sheets.	—

Secondary

Measure	Time frame
Duration of the stages of labor. Timepoint: 1 hour. Method of measurement: Data sheets.;The adverse effects in mothers. Timepoint: each hour. Method of measurement: Data sheets.;The adverse effects in neonates. Timepoint: After birth up to discharge. Method of measurement: Data sheets.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Kashanian

Iran University of Medical Sciences

maryamkashanian@yahoo.com+98 21 5563 3244

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026