Depression. Depressive episode
Conditions
Interventions
Intervention 1: Intervention group: supplements of hesperidin, capsules 200 mg orally, once a day for three months. Intervention 2: Control group: placebo containing starch, 200 mg capsules orally, on
Treatment - Drugs
Placebo
Intervention group: supplements of hesperidin, capsules 200 mg orally, once a day for three months
Control group: placebo containing starch, 200 mg capsules orally, once a day for three months
Sponsors
Vice chancellor for research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: willingness to cooperate and signed informed consent; Do not use any supplements during the last 3 months; including omega-3, 10 Q, antioxidants and vitamins; The absence of any allergies (gastrointestinal and skin) to any type of antioxidant supplements and vitamins, age 30 to 70 years; Beck Depression Inventory score more than 10; patients with MI from discharge to 6 weeks after MI; Do not use more than one blood orange or Do not use more than two other citrus fruits a day; BMI=25-40. Criteria of excluding: There are major psychiatric disorders in patients with history; treatment of depression over 1 year ago; taking more than 500 ml per day of flavonoid-rich beverages include tea, coffee, citrus juice; Major cognitive disorders or impaired cognitive function of the patient's history; Lack of follow-up after discharge; Smoking and tobacco; uncontrolled development of metabolic diseases; Pregnancy and lactation; Use heparin and warfarin. Exclusion criteria: The use of any antioxidant and vitamin supplements; View the latest allergy symptoms at any time during the study; unwillingness to continue the cooperation of the patient for any reason; uncontrolled chronic diseases ( Like: hepatic failure, renal failure, diabetes, etc.); digestive disorders; compliance below 80%; Earn each of the criteria of entry.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: Before the intervention, after the intervention. Method of measurement: Beck standard questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain-Derived Neurotrophic Factor. Timepoint: Before the intervention, after the intervention. Method of measurement: ng per ml in the ELISA.;Cortisol. Timepoint: Before the intervention, after the intervention. Method of measurement: micrograms per deciliter, ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Vafa
Vice chancellor for research, Iran University of Medical Sciences
Outcome results
None listed