The effects of ketorolac and metoclopramide when added to lidocaine for intravenous regional anesthesia ( Bier’s block)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017022532755N1

Enrollment

160

Registered

2017-04-24

Start date

2017-01-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regional anesthesia. Local anaesthetics

Interventions

lidocaine 3 mg/kg + metoclopramide 10 mg volume up to 40 ml added normal saline.

Intervention 1: Group1: premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms. Bier block

lidocaine 3 mg/ kg volume up to 40 ml with normal saline added. Intervention 2: Group 2:premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms. Bier block

lidocaine 3 mg/kg + ketorolac 20 mg volume up to 40 ml with normal saline added. Intervention 3: Group 3:premedication normal saline 200 ml + midazolam 1 mg + fentanyl 50 micro grams.Bier block

lidocaine 3 mg/kg + metoclopramide 10 mg volume up to 40 ml added normal saline. Intervention 4: Group 4:premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms.Bier block

lidocaine 3 mg/kg + metoclopramide 5 mg + ketorolac 10 mg volume up to 40 ml added normal saline.

Treatment - Drugs

Group1: premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms. Bier block

lidocaine 3 mg/ kg volume up to 40 ml with normal saline added.

Group 2:premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms. Bier block

lidocaine 3 mg/kg + ketorolac 20 mg volume up to 40 ml with normal saline added.

Group 3:premedication normal saline 200 ml + midazolam 1 mg + fentanyl 50 micro grams.Bier block

Group 4:premedication iv normal saline 200 ml + midazolam 1 mg + fentanyl 50 micrograms.Bier block

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients ASA I-II;aged 18-70 years old;come for ortopaedic surgery distal to elbow; eligible for Bier block.Exclusion criteria:raynod syndrome;sickle cell anemia;allergy to lidocaine-metoclopramide-ketorolac;history of renal disease-liver disease-gasterointestinal bleeding-Parkinson disease;history of extrapyramidal side effect to metoclopramide;administration of NSAID drugs last 24 hours;any neuronal defect in limb under surgery;addiction to opioids.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain management. Timepoint: 2; 4; 6; 12; 24 hours after surgery. Method of measurement: visual analogue scale.;Beginning of analgesia. Timepoint: After uses of anesthetic drug. Method of measurement: evaluation patients response to pin.;Dosage of analgesic drug after surgery. Timepoint: First 24 hours after surgery. Method of measurement: nursing report.	—

Secondary

Measure	Time frame
Pain the site of turnicate. Timepoint: 15 minutes after flattening of turnicate. Method of measurement: visual analogue scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr abalfazl shojaei

kashan university of medical sience

Shojaei- an@ kaums. Ac. Ir Aabalfazl@ gmail. Com+98 31 5545 6575

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026