Comparison of efficacy of Diphereline ( IPSEN, France) and Variopeptyl (Varian pharmed, IRAN) in treatment of girls with idiopathic central precocious puberty (CPP)

Comparison of efficacy of Diphereline and Variopeptyl in treatment of girls with idiopathic central precocious puberty

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170225032759N1

Enrollment

Registered

2017-12-03

Start date

2016-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

central precocious puberty. E22.8

Interventions

Intervention 1: Treatment with use of Diphereline 3.75 mg (triptorelin) manufactured by IPSEN (France) every 28 days for 3 months. Intervention 2: Treatment with use of Variopeptyl 3.75 mg (triptoreli

Treatment - Drugs

Treatment with use of Diphereline 3.75 mg (triptorelin) manufactured by IPSEN (France) every 28 days for 3 months

Treatment with use of Variopeptyl 3.75 mg (triptorelin) manufactured by IPSEN (IRAN) every 28 days for 3 months

Eligibility

Sex/Gender

Female

Age

2 Years to 8 Years

Inclusion criteria

Inclusion criteria: girls under 8 years, with confirmed central precocious puberty (CPP) signed Informed Consent Form

Exclusion criteria

Exclusion criteria: girls older 8 years

Design outcomes

Primary

Measure	Time frame
LH. Timepoint: befor intervention then 28 days after injections (days 0-28-56-84). Method of measurement: Cm.;FSH. Timepoint: befor intervention then 28 days after injections (days 0-28-56-84). Method of measurement: Iu/L.;Estradiol. Timepoint: befor intervention then 28 days after injections (days 0-28-56-84). Method of measurement: Iu/L.	—

Secondary

Measure	Time frame
Hight. Timepoint: befor intervention then 28 days after injections (days 0-28-56-84). Method of measurement: cm.;Wieght. Timepoint: befor intervention then 28 days after injections (days 0-28-56-84). Method of measurement: Kg.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahtab ordooei

Yazd University of Medical Sciences

dr.ordooei@yahoo.com+98 353183737

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026