Comparison of the effect of magnesium sulfate versus Dexmedetomidine on the quality of surgical filed in patients candidate for endoscopic sinus surgery

Comparison of the effect of magnesium sulfate versus Dexmedetomidine on the quality of surgical filed in patients candidate for endoscopic sinus surgery: a triple blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201702239014N145

Enrollment

Registered

2017-03-04

Start date

2017-03-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

candidate for endoscopic sinus surgery. During endoscopic examination

Interventions

Intervention 1: Intervention group 1: Magnesium sulfate infusion 50 mg/kg/ min for 10 min and then 15 mg/kg/h to the end of surgery. Intervention 2: Intervention group 2: Dexmedetomidine infusion 1 mi

Treatment - Drugs

Intervention group 1: Magnesium sulfate infusion 50 mg/kg/ min for 10 min and then 15 mg/kg/h to the end of surgery.

Intervention group 2: Dexmedetomidine infusion 1 micg/kg/ min for 10 min and then 0.5 micg/kg/h to the end of surgery.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients candidate for endoscopic sinus surgery; age of 18 to 60 years. Exclusion criteria: Obesity with BMI index equal to or greater than 30; renal, liver, hematological, neuromuscular or hemorrhagic disorders; diabetes; using calcium blocker or NSAIDS.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Measuring bleeding. Timepoint: at 1, 5, 15, 30 and 60 minutes after starting infusion. Method of measurement: using suction.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mahdi Shahabi Nejad

Besat Hospital

mshahabi84@yahoo.com+98 81 3838 0090

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026