Evaluation the efficacy of topical naloxane on Controlling of Chronic Prupritus Induced By Chemical Injuries

Evaluation the Efficacy and Safety of Topical Naloxane Ointment on Controlling of Chronic Prupritus Induced By Chemical Injuries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201702221165N17

Enrollment

Registered

2017-03-29

Start date

2017-03-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Prupritus Induced By Chemical Injuries. Irritant contact dermatitis

Interventions

Intervention 1: Topical naloxan 2% formulationintervention group: 35 person will recive topical naloxan formulation, two times a day (in the morning and evening) for 4 weeks. At the begining of the st

Treatment - Drugs

Placebo

Topical naloxan 2% formulationintervention group: 35 person will recive topical naloxan formulation, two times a day (in the morning and evening) for 4 weeks. At the begining of the study, standard qu

Control group: 35 person will recive topical palacebo formulation, two times a day (in the morning and evening) for 4 weeks. at the begining of the study,standard questionaris will fill by

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. self-satisfiction form should be filled by the patient; 2. the patients shouled be between 25-65 years old; 3. the Rx of pruritus induced by chemical gas shouled be diagnosed; 4. the patients shouldn’t have any other skin disorders; 5. the patients don’t use any topical steroids; 6. the patients shouldn’t be addict; 7. the patients be accessible; 8. the patients don’t leave the treatment more than one week; 9. the patients don’t have allergy to drug; 10. if the disease become uncontrolabe.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pruritus sevsrity. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.;Pruritus distribion. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.	—

Secondary

Measure	Time frame
Pruritus frequency. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.;Pruritus period. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.;Quality of sleeping. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.	—

Measure

Time frame

Pruritus frequency. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.;Pruritus period. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.;Quality of sleeping. Timepoint: at the bigging off intervention,at the end of intervention. Method of measurement: standard questionaries.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactYunes Panahi

Research Center of Baghiyatallah University

yunespanahi@yahoo.com+98 21 8821 1524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026