Pre-diabetes. Prediabetes
Conditions
Interventions
Intervention 1: Intervention group: In this study, patients in the intervention group received 2 nanocurcumin (40 mg) daily for 12 weeks (after breakfast and after dinner). The nanocurcumin drug will
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: People with prediabetes No smoking and alcohol Lack of intense physical activity Failure to follow special diets Age 18-50 years BMI = 25 kg/m2 Not taking blood glucose lowering drugs People who, after explaining the work, are willing to cooperate and answer questions and perform experiments
Exclusion criteria
Exclusion criteria: Pregnant or lactating women or deciding to become pregnant during the intervention Use of Oral contraceptive pill Suffering from certain diseases (types of malignancies and cancers, chronic and acute liver disorders), biliary disease, known autoimmune diseases, neurological and mental diseases, hereditary disorders affecting of the liver, endocrine diseases, inflammatory diseases , high blood pressure, cardiovascular diseases, pulmonary diseases, renal diseases Taking hepatotoxic drugs, blood lipid-lowering drugs, insulin, sedative drugs, blood pressure-lowering drugs History of weight loss surgery in the last year weight loss during the last 3 months Susceptibility to the supplement or lack of compliance during the intervention Concurrent participation in another plan Lake of cooperation of participants in different stages of project implementation people who lose the conditions to enter the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Weight. Timepoint: Two times, before and after intervention. Method of measurement: Weight with minimal coverage and without shoes using a SECA weight scale with an accuracy 100 grams.;BMI. Timepoint: Two times, before and after intervention. Method of measurement: Divide weight (kg) by height squares (m2).;Waist circumference. Timepoint: Two times, before and after intervention. Method of measurement: Between the lower margin of the last rib and the crown of the iliac bone at the level of the umbilicus and at the end of natural exhalation from the garment.;Blood pressure. Timepoint: Two times, before and after intervention. Method of measurement: Blood pressure is measured using a mercury sphygmomanometer after sitting for 10 minutes.;Fasting blood sugar. Timepoint: Two times, before and after intervention. Method of measurement: In the FBS test, the patient should fast for 10-12 hours. Its normal amount varies according to the kit and test method. In the enzymatic method, FBS in normal adults is 70-110 mg/dl.;Total cholesterol. Timepoint: Two times, before and after intervention. Method of measurement: The amount (TC) is measured by enzymatic methods.;Triglyceride. Timepoint: Two times, before and after intervention. Method of measurement: The amount (TG) is measured by enzymatic methods.;Fat Mass. Timepoint: Two times, before and after intervention. Method of measurement: Body composition analyzer.;Fat Free Mass. Timepoint: Two times, before and after intervention. Method of measurement: Body composition analyzer.;Hemoglobin A1c. Timepoint: Two times, before and after intervention. Method of measurement: Specific Kit for measuring the Hba1c levels.;Interlukine-6. Timepoint: Two times, before and after intervention. Method of measurement: Elisa test.;Serum TNF-a. Timepoint: Two times, before and after intervention. Method of measurement: ELISA.;BC2R gene expression. Timepoint: Two times, before and after intervention. Method of measurement: Real time PCR meth | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReyhaneh Azizi
Yazd University of Medical Sciences
Outcome results
None listed