Effect of thymus essential oil in prevention of ventilator associated pneumonia

Comparison of effectiveness of inhaled thymus essential oil with placebo in preventing Ventilator Associated Pneumonia (VAP)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170220032672N2

Enrollment

106

Registered

2018-04-23

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia. Pneumonia in other diseases classified elsewhere

Interventions

Intervention 1: Intervention group:15 drops or 1 cc thymus oil essential 1/2% on the basis of sesame oil with 9 cc distilled water every 12 hours for 10 days nebulizer. Intervention 2: Control group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Aged 18 years and above Under invasive mechanical ventilation

Exclusion criteria

Exclusion criteria: Clinical Pulmonary Infection Score (CPIS) more than 6 history of allergy sepsis acute phase Cancer trauma to the jaw, face and chest

Design outcomes

Primary

Measure	Time frame
Percentage of patients with ventilator associated pneumonia. Timepoint: CPIS measurements at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: Clinical Pulmonary Infection Score (CPIS).	—

Secondary

Measure	Time frame
Peak inspiratory pressure and plateau pressure. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data.;SpO2, SaO2. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: pulse oxymeter and arterial blood gas.;Rapid Shallow Breathing Index (RSBI). Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data.	—

Measure

Time frame

Peak inspiratory pressure and plateau pressure. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data.;SpO2, SaO2. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: pulse oxymeter and arterial blood gas.;Rapid Shallow Breathing Index (RSBI). Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Valipour Dehkordi

Hajar hospital

valipoor.somaye@yahoo.com+98 38 3222 0016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026