Calcium kidney stone. Calculus of kidney
Conditions
Interventions
Intervention 1: Intervention group: Patients taking atorvastatin oral tab (20 mg). Duration and Dosage: One daily for 3 month. Intervention 2: Control group: Patients taking placebo. Duration and Dosa
Treatment - Drugs
Placebo
Intervention group: Patients taking atorvastatin oral tab (20 mg). Duration and Dosage: One daily for 3 month.
Control group: Patients taking placebo. Duration and Dosage: One daily for 3 month
Sponsors
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: History of calcium kidney stone (stone should be radio-opaque in radiological evaluation); at least 2 times of kidney stone episodes (Recurrent stone); at least 20 days since the last treatment; age 18 to 65 years; Hyperoxaluria (24-hour urine oxalate over 40 and less than 80 mg); willingness to cooperate in the study. Exclusion criteria: Primary or enteric hyperoxaluria (urine oxalate>80 mg/24h);taking any drugs or supplements with antioxidant or anti-inflammatory effects (e.g. steroids, Nonsteroidal Antiinflammatory Drugs, pioglitazone, …), multivitamins containing vitamin A,C or E and any supplement containing anti-oxidants; History of diabetes mellitus, hepatic failure, thyroid or parathyroid diseases, cancers or immunologic diseases, chronic kidney disease (Glomerular filtration rate< 60), Urinary tract infection and chronic diarrhea; Pregnancy or lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine malondialdehyde. Timepoint: Before the intervention, 3 months after the intervention. Method of measurement: colorimetric method using Thiobarbituric acid.;Urine neutrophil gelatinase-associated lipocalin. Timepoint: Before the intervention, 3 months after the intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Morning urine pH. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Dip stick.;24 hour urine volume. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: observation.;24 hour urine creatinine. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Colorimetric.;24 hour urine calcium. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Colorimetric.;24 hour urine oxalate. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Assay kit with Enzymatic method.;24 hour urine phosphorus. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Colorimetric.;24 hour urine magnesium. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Colorimetric.;24 hour urine citrate. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Assay kit with Enzymatic method.;24 hour urine uric acid. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: Colorimetric.;24 hour urine sodium. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: flame photometry or indirect ion selective electrode.;24 hour urine potassium. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: flame photometry or indirect ion selective electrode.;24 hour urine chloride. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: flame photometry or indirect ion selective electrode.;Calcium oxalate relative supersaturation. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: calculation by lithorisk software.;Calcium phosphate relative supersaturation. Timepoint: Before the intervention,3 months after the intervention. Method of measurement: c | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSanaz Tavasoli
Urology and Nephrology Research Center
Outcome results
None listed