Major Depressive Disorder. Major Depressive Disorder
Conditions
Interventions
Intervention 1: Tablet Citalopram 40 mg/day plus Capsule palmitoylethanolamide 600 mg BID as intervention group for 6 weeks. Intervention 2: Tablet Citalopram 40 mg/day plus Capsule placebo as control
Treatment - Drugs
Placebo
Tablet Citalopram 40 mg/day plus Capsule palmitoylethanolamide 600 mg BID as intervention group for 6 weeks
Tablet Citalopram 40 mg/day plus Capsule placebo as control group for 6 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: presence of Major Depressive Disorder based on DSM-5 criteria; baseline Hamilton Depression Rating Scale (HAM-D) (17-item) score of at least 19. Exclusion criteria: presence of psychosis, any other diagnosis in axis I and II; receiving psychotropic medications; receiving any antidepressants during past one month or ECT during past two months; presence of hypothyroidism or cardiovascular problems, pregnancy or nursing women.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 2,4 and 6. Method of measurement: by Hamiltion Depression Rating Scale 17-Item. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed