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Evaluation of thiamine effect on heart failure

Evaluation of thiamine effect on early outcome in patients with low systolic ejection fraction after cardiac surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201702152622N3
Enrollment
150
Registered
2017-05-20
Start date
2017-04-07
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac failure. Heart failure

Interventions

Intervention 1: The intervention group receives Thiamine as 200 mg bolus dose during 30 minutes followed by 50 mg/hr to 24 hours. Intervention 2: The control group receives normal saline as the placeb
Treatment - Drugs
Placebo
The intervention group receives Thiamine as 200 mg bolus dose during 30 minutes followed by 50 mg/hr to 24 hours.
The control group receives normal saline as the placebo similar to Thiamine administration in intervention group.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria :CABG candidates; ejection fraction>40%; age >18 years old. Exclusion criteria: emergency operation; accompanying surgery; history of recent alcohol abuse; EF>40%; recent consumption of group B vitamins and Cefteriaxone; off pump CABG; sensitivity to group B vitamins .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood lactate level. Timepoint: 0, 6, 18, and 24 hours after intervention. Method of measurement: Bloos sample lab test.

Secondary

MeasureTime frame
Intubation time. Timepoint: During hospitalization. Method of measurement: clinical assessment.;Duration of hospitalization. Timepoint: During hospitalization. Method of measurement: Clinical Assessment.;Length of stay in ICU. Timepoint: During hospitalization. Method of measurement: Clinical Assessment.;One-month mortality. Timepoint: 1 mo after ICU admision. Method of measurement: Clinical Assessment.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Khosro Barkhordari

Tehran Heart Center hospital

kh.barkhordari@gmail.com+98 21 8802 9600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026