Study the effects of pretreatment with myoinositol on oocyte quality in patients with polycyctic ovary syndrome

Study the effects of pretreatment with myoinositol on oocyte quality in PCOS patients undergoing multiple follicular stimulation for IVF/ICSI

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017021432525N2

Enrollment

Registered

2017-04-30

Start date

2016-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrome disorder. Polycystic ovarian syndrome

Interventions

Intervention 1: myoinositol 2000 mg +400 mg folic acid daily for 3 months. Intervention 2: 400 mg folic acid daily for 3 months.

Treatment - Drugs

myoinositol 2000 mg +400 mg folic acid daily for 3 months

400 mg folic acid daily for 3 months

Eligibility

Sex/Gender

Female

Age

35 Years to 60 Years

Inclusion criteria

Inclusion criteria: inclusion criteria:infertile women with PCOS over 35 years old candidate for IVF procedure;normal sperm test and hysterosalpingography;agreement of patients for participation in the study. exclusion criteria:patients must not use any other medication during the study;any other disease,history of abdomen and pelvic surgery,male infertility,abnormal hysterosalpingography or abnormal prolactin level;patiens leave the study on their own decision

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cancelled cycles. Timepoint: 3 months after intervention. Method of measurement: observation.;Cycles which lead to freeze. Timepoint: 3 months after intervention. Method of measurement: observation.;Chemical and clinical pregnancy. Timepoint: 3 months after intervention. Method of measurement: pregnacy proved by positive beta HCG test ,14 days after ovum transportation and sonography approved.;Ovum grade. Timepoint: 3 months after intervention. Method of measurement: A -D observation.;PVS quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Ferilized egg. Timepoint: 3 months after intervention. Method of measurement: observation.;Zona pellucida quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Cleavage rate. Timepoint: 3 months after intervention. Method of measurement: observation.;Metaphase II oocytes quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Number of metaphase II oocytes. Timepoint: 3 months after intervention. Method of measurement: observation.;Number of atretic and immature oocytes (GV and metaphase II phases and degenerated oocytes). Timepoint: 3 months after intervention. Method of measurement: observation.	—

Measure

Time frame

Cancelled cycles. Timepoint: 3 months after intervention. Method of measurement: observation.;Cycles which lead to freeze. Timepoint: 3 months after intervention. Method of measurement: observation.;Chemical and clinical pregnancy. Timepoint: 3 months after intervention. Method of measurement: pregnacy proved by positive beta HCG test ,14 days after ovum transportation and sonography approved.;Ovum grade. Timepoint: 3 months after intervention. Method of measurement: A -D observation.;PVS quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Ferilized egg. Timepoint: 3 months after intervention. Method of measurement: observation.;Zona pellucida quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Cleavage rate. Timepoint: 3 months after intervention. Method of measurement: observation.;Metaphase II oocytes quality. Timepoint: 3 months after intervention. Method of measurement: observation.;Number of metaphase II oocytes. Timepoint: 3 months after intervention. Method of measurement: observation.;Number of atretic and immature oocytes (GV and metaphase II phases and degenerated oocytes). Timepoint: 3 months after intervention. Method of measurement: observation.

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Secondary

Measure	Time frame
Hospitalization rate because of OHSS( ovary hyperstimulation syndrome). Timepoint: 3 months after intervention till end of pregnancy. Method of measurement: number of hospitalizations of patiens due to this reason ,observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShadrooz Moazzam

Shahrekord University of Medical Sciences

shadeshadir@gmail.com+98 38 3222 0478

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026