Comparison of three medications in reducing blood pressure and bleeding and recovery time in sinus surgery

Comparison among remifentanil,magnesium sulphate and dexmedetomidine in decrease blood pressure and bleeding during surgery and get the exitting condition from recovery after endoscopic sinus surgery and tympanomastoidectomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017021114056N11

Enrollment

105

Registered

2017-03-01

Start date

2017-01-02

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis. Chronic sinusitis

Interventions

Intervention 1: First group receive Dexmedetomidine at dose of 1 µg/kg over 10 minutes as initial dose and 0.4 to 0.8 µg/kg/h IV infusion. Intervention 2: Second group recieve Remifentanil at dose of

Treatment - Drugs

First group receive Dexmedetomidine at dose of 1 µg/kg over 10 minutes as initial dose and 0.4 to 0.8 µg/kg/h IV infusion

Second group recieve Remifentanil at dose of 1 µg /kg over 10 minutes as initial dose and 0.25 µg/kg /min IV infusion

Third group receive Magnesium sulphate at dose of 40 µg /kg over 10 minutes before induction and 10 µg/kg /hr IV infusion

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18 to 60 years old; ASA I or II Exclusion criteria: Age lower than 18 and greater than 60; ASA greater than 2; Coagulopathies; History of cardiovascular diseases and brain vascular diseases; Poor control hypertension; Pregnancy; Opioid addiction; Body mass index greater than 35; Systolic blood pressure lower than 65 mmHg during operation; operation duration lower than 30 minutes and greater than 160 minutes

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: Sphygmomanometer.;Dyastolic blood pressure. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: Sphygmomanometer.;Bleeding volume. Timepoint: End of surgery. Method of measurement: Suctioned blood volume.;Recovery time. Timepoint: End of surgery. Method of measurement: Alderet score.	—

Measure

Time frame

Systolic blood pressure. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: Sphygmomanometer.;Dyastolic blood pressure. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: Sphygmomanometer.;Bleeding volume. Timepoint: End of surgery. Method of measurement: Suctioned blood volume.;Recovery time. Timepoint: End of surgery. Method of measurement: Alderet score.

—

Secondary

Measure	Time frame
Arterial oxygen saturation. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: pulse oximetry.;Heart rate. Timepoint: After induction and every 15 minutes until the end of operation. Method of measurement: cardiac monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesameddin Modir

Arak University of Medical Sciences

He_modir@yahoo.com+98 86 3417 3641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 25, 2026