effects of midazolam and ondansetron on nausea and vomiting after spinal anesthesia

Comparison effects of intravenous midazolam and ondansetron on nausea and vomiting after spinal anesthesia for cesarean section

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017021112251N4

Enrollment

Registered

2017-05-27

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post spainal nausea and vomiting. Other complications of anaesthesia

Interventions

Intervention 1: In First group, we will inject 20µg /kg of Midazolam IV. after clamping the umbilical cord. Intervention 2: In Second group, we will inject 4mg of ondansetron IV. after clamping the um

Prevention

In First group, we will inject 20µg /kg of Midazolam IV. after clamping the umbilical cord.

In Second group, we will inject 4mg of ondansetron IV. after clamping the umbilical cord.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 18-40 years and undergoing cesarean section; physical status class I or II in accordance with anesthesia; Term pregnancy (gestational age 36-40 weeks); Singleton pregnancy. Exclusion criteria: High-risk pregnancy; Preeclampsia; A history of liver, Mental, renal, gastrointestinal disorders and motion sickness; history of hyperemesis gravidarum; The patients who received antiemetics during previous 24 hours; history of drug addiction; history of postoperative nausea and vomiting; Patients with spinal anesthesia ban.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea and vomiting. Timepoint: Since spinal anesthesia or intravenous of midazolam or ondansetron. Method of measurement: Nausea vomiting scale.;Nausea intensity. Timepoint: Since spinal anesthesia or intravenous of midazolam or ondansetron. Method of measurement: Visual analogue scale.	—

Secondary

Measure	Time frame
Hemodynamic instability. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Heart rate. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Arterial blood oxygen saturation. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Patients' satisfaction. Timepoint: In recovery. Method of measurement: 4 point Likert scale. Including low satisfaction, average, good and excellent.	—

Measure

Time frame

Hemodynamic instability. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Heart rate. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Arterial blood oxygen saturation. Timepoint: during the surgery and recovery. Method of measurement: vital sign monitoring device.;Patients' satisfaction. Timepoint: In recovery. Method of measurement: 4 point Likert scale. Including low satisfaction, average, good and excellent.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Ghasemlo

Hospital Fatemieh

zahra_ghasemlou@yahoo.com+98 81 3827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026