COVID-19 pneumonia. COVID-19, virus identified
Conditions
Interventions
Intervention group: All patients will receive low dose whole lung irradiation for 100 Rads with 6 megavoltage photon beams in one session through two anteroposterior and posteroanterior fields by Vari
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of COVID-19 by PCR or imaging Clinical symptoms of pneumonia or Acute Respiratory Distress Syndrome (coughing, dyspnea, need for supplemental oxygen) Obvious COVID-19 pulmonary patterns in chest CT scan Age over 60 Male gender Severe/refractory lung disease associated with COVID-19 Completion of written informed consent
Exclusion criteria
Exclusion criteria: Intubation Need for continuous NIV (Non-Invasive Ventilation) Need for CPAP (Continuous Positive Airway Pressure) Pulmonary disease due to non-COVID etiologies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: Before intervention and every 6 hours after intervention. Method of measurement: Sphygmomanometer.;Length of hospital stay. Timepoint: discharge date. Method of measurement: discharge date minus admission dates.;CT score. Timepoint: 5 days after intervention. Method of measurement: Scores will range from 0-5 based on each lung lobe's percentile involvement as 0 for non-involvement, 1 for less than 5% involvement, 2 for 5-24% involvement, 3 for 25-49% involvement, 4 for 50-74% involvement and, 5 for 75-100% involvement, and the sum of each lobe score will be compared between the initial CT and the CT scan performed after discharge.;Death. Timepoint: Until discharge. Method of measurement: Death verification.;Pulse Rate. Timepoint: Before intervention and every 6 hours after intervention. Method of measurement: Pulse Oxymeter.;Respiratory rate. Timepoint: Before intervention and every 6 hours after intervention. Method of measurement: Counting in one minute by physician.;Body temperature. Timepoint: Before intervention and every 6 hours after intervention. Method of measurement: Thermometer.;Oxygen saturation. Timepoint: Before intervention and every 6 hours after intervention. Method of measurement: Pulse oxymeter. | — |
Secondary
| Measure | Time frame |
|---|---|
| SARS-CoV-2 Viral Load. Timepoint: Before the intervention and 4 days after the intervention. Method of measurement: SARS-CoV-2 Plasma PCR.;Interleukin-6. Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Interleukin-6 quantitative ELISA.;Interleukin-1. Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Interleukin-1 quantitative ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNima Mousavi Darzikolaee
Tehran University of Medical Sciences
Outcome results
None listed