Effect of rectal acetaminophen on patent ductus arteriusus (PDA) in premature neonates

Assesment of rectal acetaminophen on closure of patent ductus arteriosus in premature neonates with gestational age less than 35 weeks and post natal age 14 days that admitted in pediatric hospital doctor mohammad kermanshahi

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017020732449N1

Enrollment

Registered

2017-03-10

Start date

2017-03-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus. Patent ductus arteriosus

Interventions

Treatment begining by rectally acetaminophen with 25mg/kg loading dose and 15mg/kg Q 8 hours for 3 days. Diagnosis and response to treatment be assesed with echocardiography before and after tr

Treatment - Drugs

Treatment begining by rectally acetaminophen with 25mg/kg loading dose and 15mg/kg Q 8 hours for 3 days. Diagnosis and response to treatment be assesed with echocardiography before and after t

Eligibility

Sex/Gender

All

Age

1 Days to 14 Days

Inclusion criteria

Inclusion criteria: Inclusion criteria : premature neonates with gestational age less than 35 weeks and post natal age less than 14 days with patent ductus arteriosus. Exclusion criteria: neonate death; elevated liver enzimes more than 3 folds; G6PD; hyperbilirubinemia that required blood exchange; renal failure and NEC.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Size of patent ductus arteriosus. Timepoint: Before and after 3 days tratment period. Method of measurement: Echocardiography.	—

Secondary

Measure	Time frame
Renal function test. Timepoint: before and after 3 days treatment. Method of measurement: laboratory.;G6PD Activity. Timepoint: before begining of treatment. Method of measurement: alaboratory.;Liver enzimes. Timepoint: befor and after 3days treatment oeriod. Method of measurement: laboratory.;Bilirubin. Timepoint: before and after 3 days treatment. Method of measurement: laboratory.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maziar Vakili Amini

Kermanshah University of Medical Scienses

susiana3337@gmail.com; mzvakili@kums.ac.ir; saeed.navad@yahoo.com+98 83 3721 8206

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026