Comparison of the Effect of Ondansetron, Dexamethasone and Their Combination in Reducing Nausea and Vomiting Following Laparoscopic Cholecystectomy in patients referred to Semnan Kosar Hospital

Comparison of the Effect of Ondansetron, Dexamethasone and Their Combination in Reducing Nausea and Vomiting Following Laparoscopic Cholecystectomy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017020725732N13

Enrollment

Registered

2017-05-01

Start date

2016-09-13

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention 1: 30 cases of patients were injected 16 mg of dexamethasone intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be un

Treatment - Drugs

Intervention 1: 30 cases of patients were injected 16 mg of dexamethasone intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be unaware of the dru

Intervention 2: 30 cases of patients were injected 4 mg of ondansetron intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who will be unaware of the drugs

Intervention 3: 30 cases of patients were injected 4 mg of ondansetron plus 8 mg of dexamethasone intravenously based on a simple random sampling. Injection was performed by an anesthesiologist who wi

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: least 18 years; patients in Group ASA (one and two). Exclusion criteria: Gastroesophageal reflux; severe obesity; airway problem; pregnancy; lactation; liver or kidney disorders; a history of drug addiction; alcoholism; neuromuscular disorders; psychiatric disorders; diabetes, a history of systemic diseases (cardiovascular, respiratory and hypertension).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: In the recovery room, 6 and 24 hours after surgery. Method of measurement: View and visit (registered in the check list).;Vomit. Timepoint: In the recovery room, 6 and 24 hours after surgery. Method of measurement: View and visit (registered in the check list).;Recovery time. Timepoint: After laparoscopic cholecystectomy (from time of arrival to the recovery room). Method of measurement: In minutes.	—

Measure

Time frame

Nausea. Timepoint: In the recovery room, 6 and 24 hours after surgery. Method of measurement: View and visit (registered in the check list).;Vomit. Timepoint: In the recovery room, 6 and 24 hours after surgery. Method of measurement: View and visit (registered in the check list).;Recovery time. Timepoint: After laparoscopic cholecystectomy (from time of arrival to the recovery room). Method of measurement: In minutes.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBabak Hosein Zadeh

Semnan University of Medical Sciences

are20935@gmail.com+98 23 3345 1336

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026