Effect of vitamin E supplementation on complications in hemodialysis patients

Effect of vitamin E supplement on serum systemic and vascular inflammatory markers and lipids in hemodialysis patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017020232367N1

Enrollment

Registered

2017-04-14

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease trearment by hemodialysis. Preparatory care for dialysis

Interventions

Intervention 1: Intervention group: 200 IU oral vitamin E soft gel three times in day with breakfast, lunch and dinner meals for 10 weeks. Intervention 2: Control group: Oral vitamin E placebo three

Treatment - Drugs

Intervention group: 200 IU oral vitamin E soft gel three times in day with breakfast, lunch and dinner meals for 10 weeks

Control group: Oral vitamin E placebo three times in day with breakfast, lunch and dinner meals for 10 weeks

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Aged between 20 and 60 years; Passing at least one year of dialysis; Dialysis at least twice a week; Inclination to participate in this study Exclusion criteria: Pregnancy; Infectious, inflammatory and cardiovascular disease, thyroid gland disorders, thrombocytopenia and nutritional support (enteral and parenteral nutrition); Supplementation with omega3 and antioxidant vitamins; Taking glucocorticoids, non-steroidal anti-inflammatory, thyroxine and warfarin drugs Exclusion criteria: Unwillingness to cooperate; Kidney transplant; Not taking supplements more than 10 percent in any pursuit; Death

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum Triglycerides. Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Total cholestrol. Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Low Density Lipoprotein Cholestrol ( LDL-C ). Timepoint: Before and after of intervention. Method of measurement: Calculate according to fridval formula - mg/dl.;Serum High Density Lipoprotein Cholestrol ( HDL-C ). Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Intercellular Adhision Molecule 1 ( ICAM-1 ). Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- ng/ml.;Serum Vascular Cell Adhesion Molecule 1 ( VCAM-1 ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - ng/ml.;Serum high-sensitivity C-reactive protein ( hs-CRP ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - mg/l.;Serum Interleukin 6 ( IL-6 ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - pg/l.	—

Measure

Time frame

Serum Triglycerides. Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Total cholestrol. Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Low Density Lipoprotein Cholestrol ( LDL-C ). Timepoint: Before and after of intervention. Method of measurement: Calculate according to fridval formula - mg/dl.;Serum High Density Lipoprotein Cholestrol ( HDL-C ). Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- mg/dl.;Serum Intercellular Adhision Molecule 1 ( ICAM-1 ). Timepoint: Before and after of intervention. Method of measurement: Enzymatic method with autoanalyzer- ng/ml.;Serum Vascular Cell Adhesion Molecule 1 ( VCAM-1 ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - ng/ml.;Serum high-sensitivity C-reactive protein ( hs-CRP ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - mg/l.;Serum Interleukin 6 ( IL-6 ). Timepoint: Before and after of intervention. Method of measurement: ELISA test - pg/l.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasim Pirhadi

Tehran University of Medical Sciences, Departmant of Nutrition and Dietetic

Nasimpirhadi35@gmail.com+98 21 8895 5975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026