The effect of nitrous oxide inhaled isoferons on postoperative pain "The effect of Remifentanil propofol on postoperative pain

Comparison of inhalational Isoflurane-Nitrous oxide anesthesia and intravenous Propofol-Remifentanil anesthesia on postoperative pain in open reduction and internal fixation of leg and ankle.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170130032313N1

Enrollment

Registered

2018-06-08

Start date

2018-05-23

Completion date

Unknown

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain intensity in candidal patients for open leg and ankle surgery.

Interventions

In both groups, the patients are kept at least 8 hours fasting and prescribed by a safe line prior to anesthesia (fentanyl, one microgram per kilogram of weight). Anesthesia starts with Propofol injec

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Male or female Age between 18 until 40 ASA class 1,2 Patients with open fractures of leg & ankle

Exclusion criteria

Exclusion criteria: A history of drug use and drug abuse Anticonvulsant intake, sedative, anti-depressant Any complications that change the procedure and anesthesia

Design outcomes

Primary

Measure	Time frame
Pain score with NRS questionnaire. Timepoint: 2,4,6 hours after transfer of the ward then every 6 hours within 24 hours. Method of measurement: NRS questionnaire.	—

Secondary

Measure	Time frame
Dose of pethidine prescribed. Timepoint: 2,4,6 hours after transfer to ward then every 6 hours within 24 hours. Method of measurement: NRS questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloofar Khoobestani

Shahroud University of Medical Sciences

niloofar.kh71@yahoo.com+98 21 4422 0262

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026