Effects of alpha-lipoic acid supplementation in gestational diabetes mellitus

Alpha-lipoic acid supplementation effects on the lipid profile, antioxidant capacity and malondialdehyde in patients with gestational diabetes mellitus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017012925949N4

Enrollment

Registered

2017-02-02

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus. Diabetes mellitus arising in pregnancy

Interventions

Intervention 1: Intervention group: One capsule alpha-lipoic acid (100 mg) per day for 8 weeks. Intervention 2: Control group: One capsule placebo cellulose acetate (100 mg) per day for 8 weeks.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: No history of gestational diabetes mellitus Not consumption of vitamin and mineral supplements during the last 6 months

Exclusion criteria

Exclusion criteria: Preeclampsia Insulin therapy Oral glucose lowering drugs consumption Bed rest Alcoholism smoking

Design outcomes

Primary

Measure	Time frame
Fasting glucose. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Fasting insulin. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ELISA.;HbA1C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Chromatoghraphy.;HDL-C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;LDL-C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Friedewald’s equation.;TG. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;TC. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Malondialdehyde. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Antioxidant capacity. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.	—

Measure

Time frame

Fasting glucose. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Fasting insulin. Timepoint: Before and after 8 weeks of intervention. Method of measurement: ELISA.;HbA1C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Chromatoghraphy.;HDL-C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Spectrophotometric.;LDL-C. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Friedewald’s equation.;TG. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;TC. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Malondialdehyde. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.;Antioxidant capacity. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Colorimetric.

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Secondary

Measure	Time frame
BMI. Timepoint: Before and after 8 weeks of intervention. Method of measurement: Formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Khosrowbeygi

Arak University of Medical Sciences

a.khosrowbeygi@arakmu.ac.ir+98 86 3417 3501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026