Condition 1: pain after orthosurgery. Condition 2: nausea and vomiting after orthosurgery. Condition 3: Jaw deformity. Pain in joint Vomiting associated with other psychological disturbances Dentofacial anomaly, unspecified
Conditions
Interventions
Intervention 1: Intervention 1:Prescription of ondansetron (8 mg) (150 µg) in form of oral tablets that have been dissolved in 20 ml of water (as intervention) one hour before general anesthesia of or
Treatment - Drugs
Intervention 1:Prescription of ondansetron (8 mg) (150 µg) in form of oral tablets that have been dissolved in 20 ml of water (as intervention) one hour before general anesthesia of orthosurgery
Intervention 2:Prescription of clonidine (150 µg) in form of oral tablets that have been dissolved in 20 ml of water (as intervention) one hour before general anesthesia of orthosurgery
Sponsors
Vice chancellor for research Mashhad university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: All adult patients with ASA class I, II, age range between 18 and 40 years and BMI less than 30 kg per square meter, with jaw deformity and applicable for orthosurgery that referred to Mashhad dental school. Exclusion criteria: Patients with ASA III class and more. Patients with history of nausea in moving vehicles (Motion sickness) Patients who had experience of previous Ponv, nausea and vomiting in last 24 hours Patients with upper gastrointestinal disorders such as peptic ulcer disease, re flux, pyloric stenosis Patients with history of drug abuse and addiction Patients known to be sensitive to clonidine and ondansetron Patients with history of low blood pressure and bradycardia Patients who need to be care in ICU after surgery. Patients who not wish to continue participation in the program, for any reason.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of pain. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: VAS.;Nausea and vomiting amount after surgery. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: yes or no / dose of rescue anti emetic drug. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bradycardia. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: clinical observation.;Blood pressure. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: clinical observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Majid Eshghpour
oral and maxillofacial surgery department ,Mashhad dental school
Outcome results
None listed