Assess the efficacy of paracetamol for the closure of patent ductus arteriosus (PDA) in preterm infants.

Assess the efficacy of preventive paracetamol dosage for the closure of patent ductus arteriosus (PDA) in preterm infants.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017012718994N2

Enrollment

160

Registered

2017-03-08

Start date

2015-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus (PDA). Persistent ductus arteriosus

Interventions

Intervention 1: Intervention group: more than routine NICU management, Paracetamol with initial dosage 20 mg/kg and maintenance dosage: 7.5 mg/kg/dose every six hours for three days. Intervention 2: C

Prevention

Intervention group: more than routine NICU management, Paracetamol with initial dosage 20 mg/kg and maintenance dosage: 7.5 mg/kg/dose every six hours for three days.

Control group: only routine NICU management

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Less than 32 week gestational age Exclusion Criteria: Pulmonary artery atresia; aorta coarctation; major maternal anomalies; Hydrops fetalis; pulmonary hypertension; mortality of infants during prophylactic therapy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Ventilator usage time. Timepoint: Three days after Intervention. Method of measurement: according NICU report.;Hospitalization time. Timepoint: Three days after Intervention. Method of measurement: according NICU report.;Mortality rate of infants. Timepoint: Three days after Intervention. Method of measurement: according NICU report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Farhad Azizzadeh

Kerman University of Medical Sciences

kmu_research@yhoo.com+98 34 3132 5700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026