stroke treatment

Therapeutic effects of calcitriol on inflammatory markers and improvement of neurological symptoms in stroke patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017012532174N1

Enrollment

Registered

2017-06-06

Start date

2017-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral infarction. Cerebral infarction, unspecified

Interventions

Intervention: case group received single oral dose of 10 ug calcitriol and control group (40 patients) will receive medium change triglyceride as placebo..

Treatment - Drugs

Intervention: case group received single oral dose of 10 ug calcitriol and control group (40 patients) will receive medium change triglyceride as placebo.

Eligibility

Sex/Gender

All

Age

20 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: acute ischemic stroke; age 20-85 years old Exclusion Criteria: Hemorrhagic stroke; Vitamin D supplementation more than 800IU; High levels of calcium or phosphorus; Deep Coma

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Infact volume. Timepoint: before and 3 months after intervention. Method of measurement: CT- Scan.;Vitamine D. Timepoint: Before and 72 hours after intervention. Method of measurement: ELISA.;Calpain 1. Timepoint: Before and 24 hours after intervention. Method of measurement: flowcytometry.;IL-6. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;IL-1b. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;TNF-a. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;HSP27. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TLR4. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR and flowcytometry.;MDA. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;NO. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TAC. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TLR2. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR and flowcytometry.	—

Measure

Time frame

Infact volume. Timepoint: before and 3 months after intervention. Method of measurement: CT- Scan.;Vitamine D. Timepoint: Before and 72 hours after intervention. Method of measurement: ELISA.;Calpain 1. Timepoint: Before and 24 hours after intervention. Method of measurement: flowcytometry.;IL-6. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;IL-1b. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;TNF-a. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR.;HSP27. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TLR4. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR and flowcytometry.;MDA. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;NO. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TAC. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;TLR2. Timepoint: Before and 24 hours after intervention. Method of measurement: Real time PCR and flowcytometry.

—

Secondary

Measure	Time frame
Hypercalcemia. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.;Hyperphosphatemia. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Abolfazl Azami Tameh

Department of Anatomy, School of Medicine, Kashan University of Medical Sciences,

aazami@kaums.ac.ir?+98 31555621157

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026